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In 2024, Independence Health Group, the for-profit parent company of the nonprofit Philadelphia-based health insurance company Independence Blue Cross, reported a net loss of $239 million, despite generating $32 billion of revenue, citing a sharp increase in medical and pharmacy costs. One driver behind these losses is the rapid growth of weight-loss medications, including glucagon-like peptide-1 receptor agonists, known as GLP-1s, such as Ozempic

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A decrease in this ratio indicates increased oxidative stress, potentially triggering stress response programs such as apoptosis, necrosis, or autophagy