Patient safety guidance should include: Education about expected appetite changes and strategies for maintaining adequate nutrition Monitoring for excessive weight loss or signs of malnutrition Assessment of mental health at follow-up visits Clear instructions to report severe or persistent nausea, vomiting, or neuropsychiatric symptoms Awareness that cognitive effects remain investigational and should not influence prescribing decisions Reporting severe persistent abdominal pain (pancreatitis), right upper quadrant pain/jaundice (gallbladder disease), severe abdominal distension with inability to pass gas or stool (possible ileus), persistent vomiting or signs of dehydration, and new/worsening vision changes (retinopathy) Understanding increased hypoglycemia risk when combined with insulin or sulfonylureas GLP-1 receptor agonists are contraindicated in patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2, and should be used with caution in patients with severe gastrointestinal disease, including gastroparesis

She credited her success trying medications off-label in part to careful preparation ahead of conversations with her healthcare provider
It's particularly useful for people paying out-of-pocket because it offers discounted cash-pay pricing and home delivery
Garvey WT, Blher M, Osorto Contreras CK, et al
However, given that all patients were selected from one center, they received the same treatment and probably did not differ significantly in socioeconomic status
They're, they're like, I don't wanna lose weight