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Two structural details matter here

Patients with established type 2 diabetes treated with one to three OADs In patients with established type 2 diabetes already receiving one or two OADs, both oral and injection semaglutide demonstrated significant weight reductions compared to the respective comparators

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This is significant because, if a single valid vector can be identified (see below for criteria), it demonstrates that somatic and affective symptoms have a common core and, hence, a shared pathophysiology [25]