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Jeff Egler, Chief Medical Officer of Noom

Pathologically, AD is defined by the extracellular accumulation of amyloid beta (A) plaques and the intracellular formation of neurofibrillary tangles composed of hyperphosphorylated tau proteins

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Karim Z, Szutkowska M, Vernimmen C, et al

Kimura T, Kambe T

Mass spectrometry (positive-mode ESI-MS, TOF or Orbitrap) confirms whole molecular mass at 9,111 Da and detects synthesis post-translational modifications (Met oxidation +16, Asn/Gln deamidation +1, N-terminal pyro-glutamate)