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Conditional Breakthrough : For appropriately selected patients with access to comprehensive care and financial resources, GLP-1 agonists offer genuinely transformative therapeutic benefits

Heavy solvent use drives up the size, cost, and complexity of manufacturing facilities

The FDA has flagged safety risks for several compounded peptides, citing immunogenicity concerns and impurity questions, plus limited safety information for the proposed uses

That pricing kept treatment out of reach for many people

Flow diagrams of these cohort designs were provided in in Supplementary Figure S1-S5

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