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This creates a vicious, self-perpetuating cycle: mitochondrial dysfunction causes oxidative stress, and that oxidative stress causes further mitochondrial destruction

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In this study, once-weekly subcutaneous injections of tirzepatide (5 mg, 10 mg, or 15 mg) were compared to once-daily subcutaneous injections of titrated insulin degludec

The research team suggests there may be plausible biological reasons behind some of the reported symptoms

doi: 10.1186/s12967-025-06927-z 30