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First, we emulated two cardiovascular outcome trials, SUSTAIN-6 (semaglutide versus sitagliptin as placebo proxy) and SURPASS-CVOT (tirzepatide versus dulaglutide), to benchmark and critically evaluate our design, data and analytic framework

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However, survodutide acts on multiple metabolic pathways, so it could be useful beyond its appetite-suppressing effects, Perez noted

NCT04184622 ), and in SURPASS-2 it outperformed semaglutide on glucose and weight endpoints in type 2 diabetes ( Fras et al., NEJM 2021 )

Cash-pay alternatives when HRA, FSA, or HSA does not cover GLP-1s If your plan excludes weight-loss GLP-1s, your administrator denies the claim, or you simply want to avoid the documentation cycle, cash-pay compounded protocols are the most common alternative

PBS also plays a key role in reagent preparation