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Description

Cagrilintide is modified with a fatty acid side chain to extend its half-life, enabling once-weekly administration in research settings

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[DOI] [PubMed] [Google Scholar] 47.Wairagu PM, Phan AN, Kim MK, Han J, Kim HW, Choi JW

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Semaglutide was developed as an antidiabetic medication, but you dont need to have type 2 diabetes to experience the benefits

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Proposed pathways include modulation of multiple neurotransmitter systems (influencing serotonin, dopamine, norepinephrine, GABA, glutamate levels), possible involvement of NMDA receptors, alpha-1 adrenergic signaling (e.g., potentiating pineal acetyltransferase activity), inhibition of somatostatin release via dopaminergic routes, reduced ACTH/cortisol for stress buffering, and stimulated growth hormone or somatoliberin secretion

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If you are also interested in how other injectable treatments compare, check out the Mounjaro vs Trulicity comparison for more context on weekly injectables

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