Cagrilintide is modified with a fatty acid side chain to extend its half-life, enabling once-weekly administration in research settings
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[DOI] [PubMed] [Google Scholar] 47.Wairagu PM, Phan AN, Kim MK, Han J, Kim HW, Choi JW
Semaglutide was developed as an antidiabetic medication, but you dont need to have type 2 diabetes to experience the benefits
Proposed pathways include modulation of multiple neurotransmitter systems (influencing serotonin, dopamine, norepinephrine, GABA, glutamate levels), possible involvement of NMDA receptors, alpha-1 adrenergic signaling (e.g., potentiating pineal acetyltransferase activity), inhibition of somatostatin release via dopaminergic routes, reduced ACTH/cortisol for stress buffering, and stimulated growth hormone or somatoliberin secretion
If you are also interested in how other injectable treatments compare, check out the Mounjaro vs Trulicity comparison for more context on weekly injectables