Chem Res Toxicol 1999
Nrf2 -null mice suffer from acute hepatotoxicity after acetaminophen exposure ( Nrf2 -null mice ( Nrf2 -null mice are more susceptible to cigarette smoke-induced emphysema (Rangasamy et al., 2004), bleomycin-induced pulmonary fibrosis ( Nrf2 gene has been linked to the reduced expression of Nrf2 and subsequent lung damage caused by hyperoxia ( NRF2 gene also harbors SNPs in the promoter region (Yamamoto et al., 2004), which have been linked to the risk of acute lung injury ( Nrf2 also plays an important role in the response to intrinsic oxidative stress
Yang L, Youngblood H, Wu C, et al
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This proposed mechanism has been directly validated in animal models where the surgically severed vagus nerve attenuated anxiety- and depression-like behaviors in mice after oral antibiotic administration, providing direct evidence for neuropsychiatric effects induced by antibiotics through the gutbrain axis (Joo et al., 2023)
Exogenous supplementation replenishes depleted stores and provides additional antioxidant capacity, but it does not create a negative feedback loop that reduces the bodys own production
