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Important gene mutation types in monogenic obesity PATHOGENIC MECHANISMS AND CLINICAL MANIFESTATIONS OF MC4R -DEFICIENT OBESITY Numerous genetic screening studies in cohorts with severe early-onset obesity have confirmed that obesity due to MC4R deficiency is currently the most common cause of monogenic obesity, highlighting the critical role of MC4R in energy balance regulation [21-24]

DNA damage may be resulted from abnormal chromatin packing (37)

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Simply taking the medication alone isn't a magic bulletyou'll see the best results when you commit to comprehensive lifestyle changes