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For millennia, survival depended on storing fat during times of scarcity, leading to mechanisms that make fat loss challenging

Shah VN, Akturk HK, Kruger D, Ahmann A, Bhargava A, Bakoyannis G, Pyle L, Snell-Bergeon JK

Neck circumference drops 1 to 2 inches

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One positive thing that typically stops when you discontinue the medication: the side effects, mainly gastrointestinal discomfort like nausea, says Matthew Hayes, a psychiatry professor at the Perelman School of Medicine at the University of Pennsylvania who studies neural signaling pathways in obesity

These medications carry a boxed warning about thyroid C-cell tumors observed in rodent studies and are contraindicated in patients with personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)