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The starting dose of 0.25 mg is intentionally subtherapeutic

Same phenomenon is observed in the presence of Cys and Hcy, indicating a chemical reaction may take place between TPE-DCV and thiols which breaks down the conjugation of TPE-DCV

Requiring daily administration to sustain NNMT inhibition

Clinical follow-up data shows weight regain occurs in 5080% of patients who discontinue tirzepatide without establishing sustained dietary and activity changes

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There are a variety of contributing factors which may be present in a patient with HFpEF, including LV dysfunction (both systolic and diastolic), reduced left atrial compliance, and valvular disease, amongst others