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Serious but less common adverse effects include pancreatitis, gallbladder disease, acute kidney injury (particularly in the setting of dehydration from gastrointestinal symptoms), and hypoglycemia when used in combination with insulin or sulfonylureas

J.GranataS.MussoniM.et al (2021)

Notably, a recent study provided substantial evidence for the negative effects of NPs on human placental cells, highlighting the need to perform risk assessment studies of the impact of NPs on female reproduction and fetal development [144]

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evaluated the pharmacodynamics, pharmacokinetics, safety, and tolerability of the single and multiple up-dose oral FPN inhibitor VIT-2763 in healthy volunteers and found that VIT-2763 has a safety profile similar to placebo and is well tolerated, with no serious adverse events and discontinuations due to adverse events