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In a 2-year carcinogenicity study in CD-1 mice, subcutaneous doses of 0.3, 1 and 3 mg/kg/day (2-, 8-, and 22-fold the maximum recommended human dose [MRHD] of 2.4 mg/week, based on AUC) were administered to the males, and 0.1, 0.3 and 1 mg/kg/day (0.6-, 2-, and 5-fold MRHD) were administered to the females
In WEGOVY clinical trials in adults for weight reduction, severe gastrointestinal adverse reactions were reported more frequently among patients receiving WEGOVY (4.1%) than placebo (0.9%)
The co-injection ensures that the B6 reaches systemic circulation at the same time as the semaglutide, providing nausea coverage right when it is most needed
Updated multi-society guidance now suggests that most patients can continue GLP-1 therapy before elective procedures, including those involving anesthesia, with individualized assessment for delayed gastric emptying in patients undergoing dose-escalation phase or with significant gastrointestinal symptoms
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