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106 TNF has been involved in the process of endothelial cell activation, the induction of metalloproteinases and adhesion molecules, angiogenesis, and the regulation of fibroblast/keratinocyte/enterocyte chondrocyte/osteoclast activation, as well as other inflammatory cytokines

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Tirzepatide achieves 20.9% at 72 weeks on 15mg, per SURMOUNT-1 (Jastreboff et al., NEJM 2022)

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