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Although this new agent (cagrilintide/semaglutide) has not been addressed from a kidney perspective in clinical studies, it is known that amylin binds to G proteincoupled receptors in kidney and has been reported to influence proximal tubular sodium transport and activate the RAAS (83, 84)

However, liraglutide achieved this primarily through a pronounced reduction in palatable food intake, whereas sibutramine reduced consumption of both chow and palatable foods (Hansen et al., 2012)