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Twelve-week treatment with BOS-580, a novel, long-acting Fc-FGF-21 fusion protein, leads to a reduction in liver steatosis, liver injury, and fibrosis in patients with phenotypic NASH: A randomized, blinded, placebo-controlled phase 2A trial

Visible results typically begin around the 46 week mark, with progress building steadily from there

Proper storage documentation supports accurate clinical decision-making and prevents inappropriate dose escalation or medication switching

Supporting this, data from our functional enrichment analysis of the transcriptome revealed notable upregulation of oxidative phosphorylation and the oxidative damage response in hepsin / mice treated with saline (data not shown)

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