In Figure 4D , the HbA1c data indicate that both PNP hydrogel formulations of TZP (4.5 mg/mL) and Sema (1.8 mg/mL) effectively maintained or modestly reduced glycemic levels over 6 weeks following a single injection, demonstrating sustained therapeutic activity
However, Snyder added, treating 788 men for one year is far too few to draw conclusions about the clinical significance of the increase in coronary artery plaque volume and the cardiovascular risk of testosterone treatment. Testosterone may increase risk of heart attack and stroke by promoting vascular calcification
Any off-label use would require specialist oversight and appropriate local governance arrangements
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Drugs were administered intraperitoneally or centrally (lateral or fourth ventricle) to evaluate the potential for a forebrain and/or hindbrain central site of action
