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It exerts its anticancer effects by regulating various growth factors, protein kinases, inflammatory cytokines, and transcription factors, thereby inhibiting tumor proliferation and metastasis (228)

Furthermore, in all of these structures the C-terminal arm is aligned by the conserved guiding bar residue Asn419 hTrxR1 (Asn518 in TGR) through a strong hydrogen bond

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Overexpression of HOXA4 and HOXA9 genes promotes selfrenewal and contributes to colon cancer stem cell overpopulation