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The ulcers develop from a combination of factors, including decreased blood flow to the mucosa causing ischemia and hypoperfusion-reperfusion injury

Badamchian, M., et al

This separates it from other weight loss medications , which tend to only activate the GLP-1 and/or GIP receptors

However, the delayed gastric emptying effect may affect the absorption of some oral medications, which may need to be considered for certain drugs with narrow therapeutic windows

Whether compounded formulations with niacinamide achieve equivalent or superior absorption is unknown

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