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Only 16% of semaglutide patients did

However it isn't required

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The SURMOUNT-1 trial, published in the New England Journal of Medicine, studied tirzepatide - the dual GLP-1 and GIP agonist - in adults with obesity or overweight with at least one weight-related condition over 72 weeks

Some people take metformin for other reasons besides weight loss Because metformin is both cheap, and a relatively well-studied drug, it's often the first thing doctors reach for to treat type 2 diabetes

Taking Semaglutide with these medications can increase the risk of hypoglycemia (low blood sugar)