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B-100 complex can interfere with other medications including but not limited to levodopa, medicines containing oestrogen, hydrazine, certain anti epileptic drugs, phenobaritone, phenytoin, immunosuppressants and some medicines used to treat infections such as isoniazid, pyrazinamide, cycloserne and penicillamine

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Post-injection inflammation may present with directed severe pain, itching pain, redness, warmth, and induration, requiring treatment options such as oral analgesia, cold compresses, and avoiding immobilization of the affected limb