Moran GW, Dubeau MF, Kaplan GG, Panaccione R, Ghosh S
Metabolic benefits of annatto-extracted tocotrienol on glucose homeostasis, inflammation, and gut microbiome
77-82, PMID 10067662
Rabjohn N
MT-2 is a cyclic heptapeptide with a lactam bridge to create greater potency, prolonged duration, but also stronger agonism on MC3R and MC4R receptors, which can result in side effects like libido increase, nausea, changes in appetite, In preclinical research, MT-1 5mg is chosen when a targeted MC1R profile is desired and MT-2 as broader melanocortin activation
Pfizer's peptide-relevant pipeline includes oncology antibody-drug conjugates (which utilise peptide linker chemistry) and its manufacturing expertise in complex molecule synthesis gives it infrastructure that could support future peptide manufacturing partnerships or in-licensing opportunities