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Statin therapy is known to potentiate the effect of antihypertensive drugs [32, 33] through vasodilation, which is due to increased nitric oxide synthase activity [34], downregulation of angiotensin II-type 1 receptors [35], and endothelin-1 production [36]

Update 21 , 411426 (2015)

doi: 10.2337/dc16-1728 62 AlmandozJPWaddenTATewksburyCApovianCMFitchAArdJDet al

Patients who switched from semaglutide to orforglipron maintained a mean 79.3% of their body weight reduction compared with the placebo arm, which maintained a mean 37.6% of their weight loss