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Repeated supratherapeutic ingestion can cause toxicity in doses only slightly above the maximum daily therapeutic dose [Citation4]

Just one week of sleeping fewer than six hours per night raises the hunger hormone ghrelin, lowers the satiety hormone leptin, and increases cortisol a combination that promotes fat storage (especially around the abdomen) and increases cravings for high-calorie foods

Rapid discontinuation of opioid analgesics in patients who are physically dependent on opioids has resulted in serious withdrawal symptoms, uncontrolled pain, and suicide

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With no licensed provider monitoring your treatment, even mild symptoms can escalate without intervention

The dose was reduced from 1.0 to 0.5 mg in 12.5% of patients, primarily because of gastrointestinal disorders