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For example, when you lose weight, your body naturally tries to increase hunger hormones and decrease fullness hormones to protect its fat stores

J Diabetes Sci Technol 15(6):12161223

Made by cells lining the small intestine, this hormone has a host of different roles

Increased risk of type 2 diabetes in antidepressant users: evidence from a 6-year longitudinal study in the E3N cohort

It is readily absorbed, 60-80% bioavailable, lipophilic (meaning it is fat soluble as well as water soluble), and works its way directly into your plasma, allowing it to travel throughout your body

The one consideration is timing