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Moreover, the conversion of GGC to glutathione only requires 1 molecule of ATP as it is the product of the first step in glutathione synthesis, as shown in Figure 1

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Under IL-1 stimulation, chondrocyte mitochondrial membrane potential decreases substantially, closely correlating with mitochondrial dysfunction ( 3.2 Synovial inflammation and ferroptosis Synovial inflammation is another critical feature in the pathological progression of OA and may even precede cartilage degeneration (Scanzello and Goldring, 2012)

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