This might also be important for transplant engraftment during HSCT, as transplantation from normal donor mice to mice with iron overload resulted in a delayed hematopoietic reconstitution (107)
You're asking clinically-relevant questions, and then yeah
Analytical Methods Analytical techniques used to quantify total or individual bile acids in biological fluids include (1) gas-liquid chromatography (GLC), (2) high-performance liquid chromatography (HPLC), (3) enzymatic assay, (4) radioimmunoassay (RIA), (5) enzyme-linked immunosorbent assay (ELISA), and (6) tandem mass spectrometry (MS/MS)
Tissue-level deficiency of cobalamin is associated with an increase in the urinary and serum concentrations of an organic acid called methylmalonic acid, which is an alternative product of a cobalamin dependent pathway within the mitochondria
JCO Oncol Pract 16(8):525, 2020
NR also activates the mitochondrial UPR and prolongs the survival of SOD1 G93A mice (Zhou et al., 2020)