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Structural studies of LY3502970 have highlighted the importance of hydrophobic and aromatic contacts within the cavity to stabilize active receptor conformations

GLP-1 is synthesized and secreted from intestinal L-cells, and it is the prototype of a new class of blood glucose-lowering agents that are now in use for the treatment of type 2 diabetes mellitus (T2DM) 3

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[DOI] [PMC free article] [PubMed] [Google Scholar] 203.Algotar A., Trofymenko S., Muramoto M., Howerter A., Kutob R