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While challenging the importance of the protein binding hypothesis, it was instead suggested that the key mechanism of cell death involves P450-derived ROS formation during APAP metabolism, which triggers extensive LPO [59, 60]

CDA-HFD animals were allocated to treatment groups without randomization

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In a randomized placebo-controlled pilot study, researchers examined whether adding phentermine to patients already on liraglutide (a GLP-1 agonist) for one year would produce additional weight loss

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