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Briefly, while the extracellular domain (ECD) of GLP-1R, which is responsible for ligand recognition and specificity, engages the C-terminus of the GLP-1, the interhelical transmembrane crevice of the GLP-1R helps in docking of the N-terminus of the GLP-1, triggering downstream signaling ( FIGURE 2 However, the naturally secreted GLP-1 is quickly hydrolyzed and rendered inactive by dipeptidyl peptidase-4 (DPP-4), a transmembrane amino peptidase
[Crossref] [PubMed] Tal R, Heck M, Teloken P, et al
Incidence and risk factors associated with hypoglycemia among patients with chronic kidney disease
The honest clinical picture, however, is more measured than the marketing: both peptides are investigational , neither is FDA-approved, and human clinical evidence specific to the combination is limited
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