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Using HyPer and roGFP reporters, genetically encoded fluorescent sensor for detecting intracellular hydrogen peroxide and ROS respectively 49,52 , we confirmed that aged neurons possessed a higher level of ROS (Fig

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Cell Death Dis 5 , e1179, (2014)

This was emphasised in the CANTOS trial, in which a monoclonal antibody targeting IL-1 in individuals with established atherosclerotic CVD and evidence of systemic inflammation reduced the risk of major adverse cardiovascular events (MACE) by 1517%, an effect that was likely to be mediated by reductions in serum CRP concentrations [80, 81]

Afferent arterioles were microdissected under a stereomicroscope (SMZ1500

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