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Srinivasans team shared its findings in the December 2023 Science Advances

It is critical to heart and brain function, muscle movement, and several other body processes

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Mechanism Comparison Shared Pathway Both peptides activate GHSR-1a on pituitary somatotrophs, triggering: GHSR-1a Gq/11 PLC IP + DAG intracellular Ca release PKC activation Ca influx GH vesicle exocytosis This is fundamentally different from how GHRH analogs (CJC-1295, Sermorelin) work (GHRHR Gs cAMP PKA), which is why combining either GHRP with a GHRH analog produces synergistic GH release (Veldhuis et al., 2009)

To the best of the co-authors' knowledge, author Ze'ev Hochberg fulfils the authorship criteria in line with Frontiers policy