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The finding of a trend toward improved median OS in those experiencing imAEs is supportive of other dual ICI therapy studies, which have shown an association between imAEs and improved survival outcomes across tumor types

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The therapeutic utility of native GLP-1 is limited by its rapid degradation [2], primarily mediated by dipeptidyl peptidase-4 (DPP-4) and secondarily by neutral endopeptidases (NEPs) and renal clearance [3, 4]

A higher-strength regimen may be considered when metformin has already been tolerated, but only within labeled limits