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The breadth of systemic activity reflects the peptide's interaction with foundational signaling pathways (NO, VEGF, growth hormone receptor) that operate across nearly all tissue systems

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Translocation of HMP-2/-catenin, and the GATA transcription factors, ELT-3 and PQM-1, are required for DTC-mediated longevity induction upon germline loss

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Loren Pickart, working at the University of California San Francisco, was trying to understand why liver tissue from elderly patients (60-80 years old) showed increased fibrinogen levels compared to younger tissue