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Cureus 12:e11475 Resende NM, Vasques Bittencourt F, Gontijo B (2021) Congenital melanotic macule of the tongue: a five-year follow-up

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Monitoring for side effects is essential, particularly during the initial weeks of treatment or when doses are adjusted

In response to stress, low expression of PGC-1 results in a reduction in ATP synthesis and an increase in ROS production, which in turn leads to dopamine neuron loss or damage