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Neuropathol Appl Neurobiol 28:410417 Chretien F, Le Pavec G, Vallat-Decouvelaere AV, Delisle MB, Uro-Coste E, Ironside JW, Gambetti P, Parchi P, Creminon C, Dormont D, Mikol J, Gray F, Gras G (2004) Expression of excitatory amino acid transporter-1 (EAAT-1) in brain macrophages and microglia of patients with prion diseases

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Mitochondrial malate dehydrogenase (MDH2) converts 2-oxoglutarate to 2-HG while alcohol dehydrogenase iron containing 1 (encoded by the ADHFE1 gene) converts GHB to 2-HG and succinic semialdehyde (SSA)

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Avoid overdosing, stick to the recommended daily intake