In annual filings to state regulators for plan year 2025, some insurers cited increases in utilization of GLP-1 drugs as a contributor to rising premiums
Gastrointestinal side effects are common on GLP-1s, explains Pessah-Pollack, which includes symptoms like nausea, vomiting, diarrhea, and constipation. Theres also a rare risk of pancreatitis
Seek urgent medical attention (contact 999 or attend A&E) if you experience: Profuse sweating accompanied by severe chest pain, chest tightness, or pain radiating to the jaw or arm , which may indicate a cardiac event Sweating with severe abdominal pain , particularly if persistent or worsening, as this could signal pancreatitisa rare but serious complication of GLP-1 medications Confusion, loss of consciousness, or inability to swallow alongside sweating, suggesting severe hypoglycaemia Signs of severe dehydration including reduced urine output, extreme thirst, dizziness, or rapid heartbeat Severe allergic reaction with swelling of the face/tongue, difficulty breathing, or widespread rash Upper right abdominal pain with fever or yellowing of the skin/eyes, which could indicate gallbladder problems (a known risk with GLP-1 medications) Contact your GP or diabetes specialist nurse within 2448 hours if you notice: Frequent episodes of sweating accompanied by trembling, hunger, or palpitations, which may indicate recurrent hypoglycaemia requiring medication adjustment Night sweats that are new, persistent, or drenching, as these warrant investigation for other underlying conditions Sweating associated with persistent nausea, vomiting, or inability to tolerate food or fluids , which may require dose adjustment or additional support Unexplained fever with sweating, which could indicate infection Any sweating pattern that significantly impacts your quality of life or daily activities If you're unsure about the urgency of your symptoms, NHS 111 can provide guidance
GLP-1 signaling affects appetite and reward-related pathways in the brain
Safety & Tolerability: Semaglutides side effect profile is similar to other GLP-1 RAs: GI disturbances (nausea in ~20% of patients initially, vomiting ~10%, diarrhea ~10%)
However, missing a weekly dose can have more prolonged effects, so its crucial to stay on schedule
