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Its application to allergic disease specifically relies partly on extrapolation from its known mechanisms (Treg support, Th1/Th2 rebalancing), which are directly relevant to allergy pathophysiology

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Published data from JAMA Internal Medicine (Liu et al., 2018) and the British Journal of Clinical Pharmacology give rough averages by dose: The rise is usually most dramatic in the afternoon and evening, because oral prednisone taken in the morning peaks 4 to 8 hours after the dose