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Signs include sharp immediate pain rather than a mild pinch, faster onset of nausea or side effects, and a firm bump rather than a soft one under the skin

Michael White, head of the department of pharmacy practice at the University of Connecticut

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This is not unique to GLP-1 medications

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Subsequently, the team further found that intrathecal administration of SM has demonstrated potent, dose-dependent, and long-lasting anti-allodynic effects in neuropathic pain models induced by spinal nerve injury [72]