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Epidemiology Incidence affects ~0.2% of Caucasian population Demographics 4:1 male:female usually presents in 3rd decade of life Etiology Pathoanatomy exact mechanism is unknown, but most likely due to an autoimmune reaction to an environmental pathogen in a genetically susceptible individual

Research questions about anti-inflammatory mechanisms benefit from KPV's distinct mechanism

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Eligibility required a body mass index (BMI) of 30 kg/m or higher, or for those with at least one obesity-related comorbidity and no diabetes, a BMI of 27 kg/m or higher

Other researchers have induced performance benefits after acute carnitine supplementation using a time to exhaustion cycling test and sprints on a bicycle

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