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Key Insights Fatigue is a common but usually temporary side effect during the initial weeks or dose changes in GLP-1 therapy, caused largely by rapid calorie deficit, dehydration, and metabolic adjustments. Maintaining steady energy requires prioritising nutrient-dense meals rich in protein and complex carbohydrates, staying well hydrated, and managing electrolyte balance, which helps mitigate tiredness and supports overall metabolism. Gentle physical activity and good sleep hygiene are critical lifestyle adjustments that improve circulation, mood, and energy levels without overtaxing the body during the drug adaptation period. Persistent, worsening, or debilitating fatigue should prompt medical evaluation to exclude other causes, reassess medication dosing, and ensure safe continuation of GLP-1 therapy under healthcare supervision. Frequently asked questions Why do GLP-1 medications cause fatigue

Unlike many other antioxidants that we get exclusively from our diet (like Vitamin C), glutathione is produced primarily in the liver and then distributed throughout the body

When the heart beats too slowly, less than 50 bpm, it is called bradycardia

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doi: 10.1159/000086988

Vitamin B12 (Cyanocobalamin): One of the most well-known energy-boosting vitamins, B12 helps convert carbohydrates into glucose and supports healthy nerve function