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Pontzer H, Raichlen DA, Wood BM, et al

In GH, reactive oxygen species (ROS) contribute to the thyroid and peripheral tissues damage

All three are connected, all under one roof

But in clinical practice, these terms are often used interchangeably for the same lesion

Notably, these biomarkers are not solely metabolic but also reflect chronic inflammatory and immunometabolic stress (for example, oxidative stress, impaired mitochondrial health and immunoendocrine signaling)