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Frontal cortex concentrations increased by 50% from 2016 to 2024, with dementia cases exhibiting higher accumulation than controls (Nihart et al., 2025)

J Nutr Biochem 2015, 26 (9), 921928

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Molecular modeling indicates that the substitution of a valine to glutamic acid at residue 411 reduces the binding affinity of linolenic acid, a reported exogenous ligand for the NHR-49 ortholog, HNF4, as well as other potential fatty acid binding partners with comparable structure (Supplementary Fig

Further research is required to fully elucidate the therapeutic potential surrounding GSH catabolism and the supply of amino acids to cancers