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77 A Cochrane review of the use of NAC in children with respiratory infections evaluated the safety data from 34 clinical trials, involving 2064 children, and found NAC to be safe, although the authors note that 59 cases of paradoxically increased bronchorrhoea (increased sputum production) in infants under the age of 2 years were reported to the French pharmacovigilance system

154 Clarke et al

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The Metabolism of Berberine and its Contribution to the Pharmacological Effects