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Alarm bells should be ringing because the study shows a rise in obesity over the last 35 years

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Clinicians should maintain perspective: the substantial metabolic benefits of tirzepatideincluding HbA1c reduction averaging 2.0-2.5% in type 2 diabetes trials (SURPASS) and weight loss of 15-20% in obesity trials (SURMOUNT)may confer overall cardiovascular benefit that outweighs any theoretical concerns about clotting risk, though this requires confirmation from long-term outcome studies

Whats more, the studies we do have suggest that some injectable peptides could trigger abnormal immune system responses, leading to allergic reactions (including severe ones like anaphylaxis) or autoimmune issues in some people

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