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In detail, no Nox3-expressing OHC either with or without cisplatin treatment could be detected in WT animals, while weak Nox3-expression in IHCs and strong Nox3 expression in supporting cells could be observed at least after cisplatin treatment

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Functions of Nox3 in the Vestibular System While the effects of Nox3 deficiency on otoconial development were described in vivo by Paffenholz and colleges [370], it took 2 years until an indirect hint for the precise mechanism of Nox3-derived ROS in this process was discovered by Kiss et al