If considering a dose reduction for maintenance: Wait until weight has stabilized for at least 4 weeks at your current dose Reduce by one dose step (e.g., 12mg to 8mg), do not jump multiple steps Monitor weight closely for 8 weeks after the reduction If weight begins to increase, return to the previous maintenance dose The phase 3 trials specifically tested 4mg as a maintenance dose, suggesting Lilly sees viability in lower maintenance doses What happens if you stop Weight regain after discontinuing GLP-1 agonists is well documented with semaglutide and tirzepatide
Revised: May 2025 INSTRUCTIONS FOR USE LANTUS SOLOSTAR (LAN-tus) (insulin glargine) injection, for subcutaneous use 3 mL Single-Patient-Use PREFILLED PEN: 100 units/mL (U-100) Read these Instructions for Use before you start taking the LANTUS Solostar pen and each time you get a new LANTUS SoloStar pen
For example, shortchanging sleep has been associated with weight gain, reduced immunity, high blood pressure, and depression
Because the body will have more fat than muscle and be less effective at burning calories, weight loss is probably just temporary
All of the interaction concerns with GLP-1 medications apply to nicotinic acid at pharmacologic doses
and Metabolism 105 (5), 15521563
