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As a result, real-world titration patterns often differ significantly from those studied in controlled environments

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Bueno NB, de Melo IS, de Oliveira SL, da Rocha Ataide T, et al

Drake CT, Terman GW, Simmons ML, Milner TA, Kunkel DD, Schwartzkroin PA et al (1994)

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Sleep quality and stress management also significantly influence metabolic function, with poor sleep and chronic stress associated with insulin resistance and weight gain