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If you start with twice daily and notice any redness, itching, or flaking, scale back to once daily

AHK-Cu alanine-histidine-lysine complexed with copper(II) is used topically, and topical copper peptides have a reputation for being well tolerated

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Indeed, the evolution of increased zinc-affinity appears rather well-established in NDM-type MBLs, of which more than 20 new allelic variants have arisen within the past decade, all with increased zinc affinity